C5orf46

Across TCGA patient cohorts, C5orf46 mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible C5orf46-associated genes across cancer lineages are HIKESHIP1, LINC01848, and RN7SL351P. Each is linked with C5orf46 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5orf46-to-partner and partner-to-C5orf46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIKESHIP1 grouped by C5orf46-low versus C5orf46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf46→partner) and Y-score (partner→C5orf46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HIKESHIP1 →	+0.390	+3.668	.006	.007	3	2
UCEC	LINC01848 →	+0.130	+3.717	<.001	.005	3	2
SKCM	RN7SL351P →	+0.363	+4.085	<.001	.001	3	2
BLCA	SNORD116-5 →	+0.298	+7.640	<.001	.009	3	2
SKCM	HMGB1P9 →	+0.148	+3.981	.002	.002	3	2
SKCM	MIR6880 →	+0.480	+3.744	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

HIKESHIP1 by C5orf46 expression — UCEC

Explore this box plot interactively →