C5orf46

Across TCGA pan-cancer cohorts, C5orf46 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated C5orf46 data layer compared with 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C5orf46 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C5orf46 expression acts as an unfavorable survival marker, although some lineages such as DLBC and LUAD show a favorable association.

HNSC, MESO, and KIRP are the cancer types where C5orf46 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.698	0.803	<.001	92	view →
MESO	OS	Median	All	0.279	0.509	<.001	85	view →
KIRP	OS	Tertile	All	0.864	0.967	<.001	62	view →
CESC	DFS	Median	All	0.755	0.882	.001	60	view →
KICH	DFS	Tertile	All	0.634	1.000	.001	38	view →
DLBC	DFS	Tertile	III,IV	1.000	0.070	.002	33	view →
KIRC	DFS	Tertile	All	0.449	0.826	<.001	31	view →
UCEC	OS	Median	All	0.836	0.907	.004	30	view →
OV	DFS	Tertile	All	0.488	0.606	.012	28	view →
LUSC	OS	Median	All	0.372	0.612	.002	28	view →
BRCA	OS	Median	II,III,IV	0.881	0.941	.001	25	view →
COAD	DFS	Tertile	All	0.559	0.781	.007	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

C5orf46–HNSC (OS)

Open the HNSC breakdown →