C5orf22

Across TCGA patient cohorts, C5orf22 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,221 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible C5orf22-associated proteins across cancer lineages are NSUN2, PAIP1, and GOLPH3. Each is linked with C5orf22 in more than 7 cancer types. Because this analysis shows association rather than direction, both C5orf22-to-partner and partner-to-C5orf22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C5orf22 versus NSUN2 in LUAD, with a Pearson correlation of 0.59.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf22→partner) and Y-score (partner→C5orf22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NSUN2 →	+0.436	+0.527	<.001	<.001	3	8
LSCC	PAIP1 →	+0.532	+0.769	<.001	<.001	3	7
OV	GOLPH3 →	+0.500	+0.720	<.001	<.001	3	6
LSCC	TARS1 →	+0.368	+0.593	<.001	<.001	3	5
LUAD	TOP2A →	+0.882	+0.476	<.001	<.001	3	5
LSCC	WDR70 →	+0.464	+0.689	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,221 associations by consensus.

C5orf22 vs NSUN2 — LUAD

Explore this scatter interactively →