C5AR2

Across TCGA patient cohorts, C5AR2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C5AR2-associated genes across cancer lineages are p62 Lck ligand, Tuberin, and INPP4B. Each is linked with C5AR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5AR2-to-partner and partner-to-C5AR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by C5AR2-low versus C5AR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5AR2→partner) and Y-score (partner→C5AR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.374	+2.817	.036	.036	3	1
UCEC	Tuberin →	+0.393	+3.169	.007	.020	3	1
UCEC	INPP4B →	-0.422	-3.000	.017	.036	2	1
UCEC	Caspase-8 →	-0.337	-3.000	.014	.036	2	1
UCEC	BRCA2 →	-0.175	-3.162	.012	.019	1	1
UCEC	Cyclin-B1 →	+0.695	+3.169	.024	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

p62 Lck ligand by C5AR2 expression — UCEC

Explore this box plot interactively →