C5AR2

Across TCGA pan-cancer cohorts, C5AR2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of C5AR2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where C5AR2 RNA is repressed in tumor relative to normal tissue. In most cancer types C5AR2 is over-expressed in tumor, although a few such as KIRP and LUSC show the opposite, repressed pattern.

KIRP, THCA, and LIHC are the cancer types where C5AR2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C5AR2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	III,IV	−1.379	<.001	11	view →
THCA	Female	III,IV	+1.026	<.001	10	view →
LIHC	All	III,IV	+1.382	<.001	8	view →
BRCA	All	III,IV	+1.141	<.001	6	view →
LUSC	Female	II,III,IV	−1.171	<.001	5	view →
KIRC	Male	II,III,IV	−0.509	<.001	5	view →
STAD	All	II,III,IV	+0.217	.004	4	view →
KICH	Female	III,IV	+1.506	.007	2	view →
UCEC	All	All	+0.483	.045	2	view →
BLCA	All	All	−0.355	.039	2	view →
HNSC	All	All	+0.255	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

C5AR2–KIRP

Open the KIRP breakdown →