C5

Across TCGA patient cohorts, C5 mutation is significantly associated with the RNA expression of many other genes, with 4,977 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C5-associated genes across cancer lineages are SYCE2, MED28P8, and GPR143. Each is linked with C5 in more than 2 cancer types. Because this analysis shows association rather than direction, both C5-to-partner and partner-to-C5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYCE2 grouped by C5-low versus C5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5→partner) and Y-score (partner→C5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SYCE2 →	+0.335	+1.642	.004	.005	3	3
HNSC	MED28P8 →	+0.087	+3.387	<.001	.006	3	3
UCEC	GPR143 →	-0.728	-2.842	<.001	<.001	3	3
UCEC	NUP43 →	+0.391	+2.595	<.001	<.001	3	3
UCEC	NDUFAF4 →	+0.422	+2.201	.001	.001	3	3
UCEC	DUT →	+0.433	+2.435	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,977 associations by consensus.

SYCE2 by C5 expression — SKCM

Explore this box plot interactively →