C4orf50

Across TCGA patient cohorts, C4orf50 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4orf50-associated genes across cancer lineages are NDRG1_pT346, 14-3-3_beta, and MSH2. Each is linked with C4orf50 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf50-to-partner and partner-to-C4orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDRG1_pT346 grouped by C4orf50-low versus C4orf50-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf50→partner) and Y-score (partner→C4orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NDRG1_pT346 →	-0.746	-3.000	.037	.035	3	1
UCEC	14-3-3_beta →	-0.115	-2.973	.018	.035	3	1
UCEC	MSH2 →	-0.371	-2.459	<.001	.020	3	1
UCEC	PEA-15_pS116 →	+0.467	+2.459	.005	.020	3	1
UCEC	STAT3_pY705 →	-0.419	-3.169	<.001	.018	3	1
UCEC	Stathmin →	+0.164	+3.584	.013	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

NDRG1_pT346 by C4orf50 expression — SKCM

Explore this box plot interactively →