C4orf50

Across TCGA cell cohorts, C4orf50 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C4orf50-associated genes across cancer lineages are OR1L6, C2orf80, and C6orf118. Each is linked with C4orf50 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf50-to-partner and partner-to-C4orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by C4orf50-low versus C4orf50-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf50→partner) and Y-score (partner→C4orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	1
BONE	C2orf80 →	+0.126	+5.169	<.001	.004	3	1
LARGE_INTESTINE	C6orf118 →	+0.175	+3.793	<.001	.007	3	1
LARGE_INTESTINE	BPIFB6 →	+0.020	+4.437	<.001	.004	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	INSRR →	+0.039	+4.584	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

OR1L6 by C4orf50 expression — BONE

Explore this box plot interactively →