C4orf50

Across TCGA cell cohorts, C4orf50 mutation is significantly associated with the mutation status of many other genes, with 3,369 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C4orf50-associated genes across cancer lineages are EPG5, PLIN4, and TBX15. Each is linked with C4orf50 in more than 3 cancer types. Because this analysis shows association rather than direction, both C4orf50-to-partner and partner-to-C4orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPG5 grouped by C4orf50-low versus C4orf50-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf50→partner) and Y-score (partner→C4orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	EPG5 →	+5.000	+4.437	.007	.007	1	4
BONE	PLIN4 →	+5.000	+4.437	.007	.007	1	4
BONE	TBX15 →	+5.000	+4.437	.007	.007	1	4
SOFT_TISSUE	TTLL12 →	+4.502	+5.066	.007	.007	1	4
SKIN	THSD7A →	+2.977	+4.392	.005	.005	1	4
SOFT_TISSUE	ANKS1A →	+4.502	+5.066	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,369 associations by consensus.

EPG5 by C4orf50 expression — BONE

Explore this box plot interactively →