C4BPA

Across TCGA patient cohorts, C4BPA mutation is significantly associated with the RNA expression of many other genes, with 1,172 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4BPA-associated genes across cancer lineages are RNU6-110P, RPL35AP3, and KRTAP9-4. Each is linked with C4BPA in more than 1 cancer types. Because this analysis shows association rather than direction, both C4BPA-to-partner and partner-to-C4BPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-110P grouped by C4BPA-low versus C4BPA-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4BPA→partner) and Y-score (partner→C4BPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU6-110P →	+0.741	+4.445	<.001	.005	3	2
READ	RPL35AP3 →	+0.553	+4.533	<.001	.004	3	2
READ	KRTAP9-4 →	+0.185	+4.421	<.001	.009	3	2
SKCM	SEC61B →	+0.294	+3.234	.008	.008	3	2
SKCM	PPP6C →	+0.337	+2.472	.009	.001	3	2
SKCM	ACO1 →	+0.535	+2.446	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,172 associations by consensus.

RNU6-110P by C4BPA expression — READ

Explore this box plot interactively →