C4BPA

Across TCGA pan-cancer cohorts, C4BPA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C4BPA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where C4BPA RNA is repressed in tumor relative to normal tissue. In most cancer types C4BPA is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and LUSC are the cancer types where C4BPA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C4BPA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.274	<.001	10	view →
LUAD	All	III,IV	−4.073	<.001	9	view →
LUSC	Male	II,III,IV	−6.435	<.001	8	view →
BRCA	All	IV	−2.935	<.001	8	view →
CHOL	All	All	−4.084	<.001	5	view →
KIRP	Male	All	+1.199	.001	4	view →
BLCA	Male	IV	−0.210	.005	4	view →
STAD	All	All	+1.214	.003	3	view →
LIHC	Female	All	−2.067	.005	2	view →
THCA	Male	II,III,IV	−0.080	.030	2	view →
COAD	All	II,III,IV	+0.704	.028	1	view →
HNSC	Female	IV	−0.106	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C4BPA–KICH

Open the KICH breakdown →