C4BPA

Across TCGA pan-cancer cohorts, C4BPA RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated C4BPA data layer compared with 5 for mutation status and 9 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher C4BPA RNA is associated with better overall survival. In most high-consensus cancer types, elevated C4BPA expression acts as an unfavorable survival marker, although some lineages such as UCEC and LIHC show a favorable association.

UCEC, KIRC, and LIHC are the cancer types where C4BPA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.750	0.604	<.001	102	view →
KIRC	OS	Median	All	0.516	0.717	<.001	102	view →
LIHC	OS	Median	II,III,IV	0.753	0.465	<.001	67	view →
LUSC	DFS	Tertile	All	0.687	0.826	.001	66	view →
OV	OS	Tertile	II,III,IV	0.878	0.788	.006	38	view →
ESCA	OS	Median	All	0.659	1.000	.020	33	view →
BRCA	DFS	Median	All	0.561	0.482	<.001	33	view →
BLCA	DFS	Median	III,IV	0.242	0.495	.002	32	view →
PAAD	OS	Quartile	All	0.224	0.676	.009	30	view →
THYM	DFS	Quartile	All	0.808	1.000	.004	29	view →
LUAD	DFS	Quartile	All	0.596	0.346	<.001	22	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

C4BPA–UCEC (OS)

Open the UCEC breakdown →