C4BPA

Across TCGA patient cohorts, C4BPA mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4BPA-associated genes across cancer lineages are MIG-6, mTOR_pS2448, and mTOR. Each is linked with C4BPA in more than 1 cancer types. Because this analysis shows association rather than direction, both C4BPA-to-partner and partner-to-C4BPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by C4BPA-low versus C4BPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4BPA→partner) and Y-score (partner→C4BPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIG-6 →	+0.097	+1.861	.007	.005	3	2
UCEC	mTOR_pS2448 →	-0.175	-2.794	.001	.003	3	2
UCEC	mTOR →	-0.156	-1.847	.008	.008	3	2
UCEC	4E-BP1 →	+0.355	+3.584	<.001	.002	3	2
UCEC	Cyclin-B1 →	+0.744	+2.906	<.001	.001	3	2
UCEC	53BP1 →	+0.334	+3.169	.007	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

MIG-6 by C4BPA expression — UCEC

Explore this box plot interactively →