C4BPA

Across TCGA cell cohorts, C4BPA mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. CNS shows the largest number of these associations.

The most reproducible C4BPA-associated genes across cancer lineages are CHRNB3, ADAM18, and AHSP. Each is linked with C4BPA in more than 1 cancer types. Because this analysis shows association rather than direction, both C4BPA-to-partner and partner-to-C4BPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHRNB3 grouped by C4BPA-low versus C4BPA-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4BPA→partner) and Y-score (partner→C4BPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CHRNB3 →	+0.037	+3.584	<.001	.003	3	2
CNS	ADAM18 →	+0.052	+3.201	.004	.008	3	1
CNS	AHSP →	+0.175	+3.321	<.001	.006	3	1
CNS	RNF212B →	+0.221	+4.300	<.001	.001	3	1
CNS	ZNF735 →	+0.323	+3.459	<.001	.006	3	1
SKIN	OR5M11 →	+0.072	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CHRNB3 by C4BPA expression — CNS

Explore this box plot interactively →