C3orf80

Across TCGA cell cohorts, C3orf80 mutation is significantly associated with the mutation status of many other genes, with 20 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible C3orf80-associated genes across cancer lineages are VMO1, C12orf56, and RASA3. Each is linked with C3orf80 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf80-to-partner and partner-to-C3orf80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VMO1 grouped by C3orf80-low versus C3orf80-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf80→partner) and Y-score (partner→C3orf80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	VMO1 →	+5.502	+5.502	.003	.003	1	1
LUNG_SCLC	C12orf56 →	+4.502	+5.066	.007	.007	1	1
LUNG_SCLC	RASA3 →	+4.502	+5.066	.007	.007	1	1
LUNG_SCLC	ZNF555 →	+5.502	+5.502	.003	.003	1	1
LUNG_SCLC	ARHGAP30 →	+5.502	+5.502	.003	.003	1	1
LUNG_SCLC	ZNF705A →	+5.502	+5.502	.003	.003	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

VMO1 by C3orf80 expression — LUNG_SCLC

Explore this box plot interactively →