C2orf74

Across TCGA patient cohorts, C2orf74 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,138 significant associations in total. GBM shows the largest number of these associations.

The most reproducible C2orf74-associated proteins across cancer lineages are C2orf74_S153, NAA20, and XRCC6_S520. Each is linked with C2orf74 in more than 5 cancer types. Because this analysis shows association rather than direction, both C2orf74-to-partner and partner-to-C2orf74 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C2orf74 versus C2orf74_S153 in LSCC, with a Pearson correlation of 0.67.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf74→partner) and Y-score (partner→C2orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C2orf74_S153 →	+0.903	+0.506	<.001	<.001	3	6
OV	NAA20 →	-0.386	-0.569	<.001	.007	3	4
OV	XRCC6_S520 →	-0.779	-0.775	.003	.004	3	4
OV	ZWILCH →	-0.598	-0.703	.008	.001	3	3
LSCC	ATL1_S23 →	+0.536	+0.310	.002	.004	3	3
LUAD	AGO1 →	+0.175	+0.315	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,138 associations by consensus.

C2orf74 vs C2orf74_S153 — LSCC

Explore this scatter interactively →