C2orf74

Across TCGA cell cohorts, C2orf74 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,382 significant associations in total. BONE shows the largest number of these associations.

The most reproducible C2orf74-associated GO terms across cancer lineages are Cardiac muscle cell action potential, Formation of translation preinitiation complex, and Negative regulation of apoptotic signaling pathway. Each is linked with C2orf74 in more than 7 cancer types. Because this analysis shows association rather than direction, both C2orf74-to-partner and partner-to-C2orf74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cardiac muscle cell action potential grouped by C2orf74-low versus C2orf74-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf74→partner) and Y-score (partner→C2orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Cardiac muscle cell action potential →	-0.168	-1.439	.005	.003	2	8
BLOOD_Lymphoma	Formation of translation preinitiation complex →	+0.099	+1.211	<.001	<.001	3	6
BONE	Negative regulation of apoptotic signaling pathway →	+0.073	+0.943	.003	.001	3	6
BLOOD_Lymphoma	Cellular response to unfolded protein →	+0.051	+0.794	<.001	<.001	3	6
BLOOD_Lymphoma	Response to topologically incorrect protein →	+0.048	+0.849	<.001	<.001	3	6
SOFT_TISSUE	Post-translational protein targeting to membrane, translocation →	+0.094	+2.021	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,382 associations by consensus.

Cardiac muscle cell action potential by C2orf74 expression — PANCREAS

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