C2orf74

Across TCGA cell cohorts, C2orf74 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C2orf74-associated genes across cancer lineages are OR10W1, SIGLECL1, and OR10Q1. Each is linked with C2orf74 in more than 1 cancer types. Because this analysis shows association rather than direction, both C2orf74-to-partner and partner-to-C2orf74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by C2orf74-low versus C2orf74-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf74→partner) and Y-score (partner→C2orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.019	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	SIGLECL1 →	+0.021	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	OR10Q1 →	+0.105	+3.920	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR10W1 by C2orf74 expression — LARGE_INTESTINE

Explore this box plot interactively →