C2orf49

Across TCGA cell cohorts, C2orf49 mutation is significantly associated with the drug of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C2orf49-associated genes across cancer lineages are Ruxolitinib, GSK690693, and JAK1_8709. Each is linked with C2orf49 in more than 1 cancer types. Because this analysis shows association rather than direction, both C2orf49-to-partner and partner-to-C2orf49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ruxolitinib grouped by C2orf49-low versus C2orf49-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf49→partner) and Y-score (partner→C2orf49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Ruxolitinib →	+0.391	+2.646	.010	.047	3	1
LARGE_INTESTINE	GSK690693 →	+0.718	+2.652	.003	.045	3	1
LARGE_INTESTINE	JAK1_8709 →	+0.428	+2.649	.030	.046	1	1
LARGE_INTESTINE	765771 →	+0.375	+2.649	.028	.046	1	1
LARGE_INTESTINE	Gallibiscoquinazole →	+0.399	+2.649	.014	.046	1	1
LARGE_INTESTINE	L-Oxonoreleagnine →	+0.361	+2.777	.013	.038	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Ruxolitinib by C2orf49 expression — LARGE_INTESTINE

Explore this box plot interactively →