C2orf49

Across TCGA pan-cancer cohorts, C2orf49 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated C2orf49 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher C2orf49 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C2orf49 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BRCA show a favorable association.

KIRP, LIHC, and ACC are the cancer types where C2orf49 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.802	0.933	.003	93	view →
LIHC	DFS	Quartile	All	0.390	0.610	<.001	79	view →
ACC	DFS	Median	All	0.405	0.746	<.001	66	view →
UVM	DFS	Tertile	III,IV	0.233	0.860	.001	54	view →
SKCM	OS	Quartile	All	0.377	0.223	.003	38	view →
MESO	DFS	Tertile	All	0.267	0.466	.009	33	view →
HNSC	OS	Quartile	III,IV	0.604	0.895	.003	25	view →
BRCA	OS	Tertile	III,IV	0.955	0.847	.008	24	view →
THYM	DFS	Tertile	All	1.000	0.578	.004	18	view →
KIRC	DFS	Tertile	All	0.859	0.705	.009	18	view →
LUAD	DFS	Quartile	III,IV	0.699	0.371	.007	17	view →
LUSC	OS	Quartile	All	0.817	0.714	.011	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

C2orf49–KIRP (DFS)

Open the KIRP breakdown →