C2orf49

Across TCGA pan-cancer cohorts, C2orf49 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of C2orf49’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where C2orf49 RNA is repressed in tumor relative to normal tissue. In most cancer types C2orf49 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where C2orf49 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C2orf49 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.752	<.001	11	view →
HNSC	All	III,IV	+0.490	<.001	10	view →
LIHC	All	II,III,IV	+0.652	<.001	9	view →
COAD	Male	All	+0.555	<.001	6	view →
BRCA	Female	All	−0.315	<.001	6	view →
CHOL	Male	All	+1.741	<.001	5	view →
KICH	Female	All	−1.281	<.001	5	view →
UCEC	All	All	−0.453	.019	4	view →
LUAD	All	IV	+0.745	.009	2	view →
STAD	All	II,III,IV	+0.428	.023	2	view →
LUSC	Male	All	+0.323	.002	2	view →
BLCA	All	All	+0.262	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

C2orf49–THCA

Open the THCA breakdown →