C2CD6

Across TCGA patient cohorts, C2CD6 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2CD6-associated genes across cancer lineages are JNK2, ERK2, and GAPDH. Each is linked with C2CD6 in more than 2 cancer types. Because this analysis shows association rather than direction, both C2CD6-to-partner and partner-to-C2CD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by C2CD6-low versus C2CD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2CD6→partner) and Y-score (partner→C2CD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.184	+1.440	<.001	<.001	3	3
UCEC	ERK2 →	+0.140	+1.584	.004	.002	3	2
UCEC	GAPDH →	+0.428	+2.137	.001	<.001	3	2
UCEC	p70-S6K_pT389 →	-0.186	-2.137	<.001	<.001	3	2
UCEC	ASNS →	+0.328	+1.584	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.512	+1.756	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

JNK2 by C2CD6 expression — UCEC

Explore this box plot interactively →