C2CD6

Across TCGA pan-cancer cohorts, C2CD6 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of C2CD6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where C2CD6 RNA is repressed in tumor relative to normal tissue. In most cancer types C2CD6 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, LUAD, and LUSC are the cancer types where C2CD6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C2CD6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.287	<.001	11	view →
LUAD	Male	All	+0.726	<.001	8	view →
LUSC	All	All	+0.377	<.001	4	view →
BRCA	All	III,IV	−0.276	<.001	4	view →
HNSC	Female	III,IV	+0.065	.007	4	view →
CHOL	All	All	+0.593	<.001	2	view →
COAD	Female	II,III,IV	−0.051	.010	2	view →
LIHC	All	All	+0.074	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

C2CD6–KICH

Open the KICH breakdown →