C2CD6

Across TCGA pan-cancer cohorts, C2CD6 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated C2CD6 data layer compared with 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher C2CD6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C2CD6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

UCEC, LUAD, and UVM are the cancer types where C2CD6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.532	0.734	<.001	84	view →
LUAD	DFS	Quartile	All	0.878	0.679	<.001	65	view →
UVM	DFS	Tertile	III,IV	0.208	0.854	<.001	62	view →
HNSC	DFS	Tertile	IV	0.458	0.266	<.001	52	view →
KIRC	DFS	Median	II,III,IV	0.435	0.605	.003	44	view →
BLCA	DFS	Median	III,IV	0.252	0.473	.002	43	view →
LGG	DFS	Median	All	0.665	0.794	<.001	37	view →
BRCA	DFS	Tertile	IV	0.917	0.354	.003	27	view →
ACC	OS	Tertile	All	0.703	0.888	.006	27	view →
KIRP	DFS	Quartile	All	0.549	0.736	.014	24	view →
LUSC	DFS	Median	II,III,IV	0.697	0.378	.006	18	view →
SKCM	OS	Tertile	All	0.850	0.903	.016	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

C2CD6–UCEC (DFS)

Open the UCEC breakdown →