C2CD2

Across TCGA cell cohorts, C2CD2 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible C2CD2-associated genes across cancer lineages are C12orf40, OR2AJ1, and TRIM49D2. Each is linked with C2CD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both C2CD2-to-partner and partner-to-C2CD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf40 grouped by C2CD2-low versus C2CD2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2CD2→partner) and Y-score (partner→C2CD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	2
LUNG_NSCLC_LUAD	OR2AJ1 →	+0.015	+3.734	<.001	.006	3	2
LUNG_NSCLC_LUAD	TRIM49D2 →	+0.047	+4.215	<.001	.002	3	2
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	OR2AK2 →	+0.070	+4.029	<.001	.009	3	1
SKIN	TMCO5A →	+0.062	+4.977	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

C12orf40 by C2CD2 expression — OVARY

Explore this box plot interactively →