C22orf31

Across TCGA patient cohorts, C22orf31 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C22orf31-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and Ku80. Each is linked with C22orf31 in more than 1 cancer types. Because this analysis shows association rather than direction, both C22orf31-to-partner and partner-to-C22orf31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by C22orf31-low versus C22orf31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C22orf31→partner) and Y-score (partner→C22orf31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.121	-3.295	.005	.009	3	1
UCEC	EGFR_pY1068 →	-0.265	-3.321	.015	.010	3	1
UCEC	Ku80 →	+0.280	+2.128	.006	.010	3	1
UCEC	PDCD4 →	-0.534	-3.312	.009	.010	3	1
UCEC	Rab25 →	-0.454	-2.115	.001	.019	3	1
UCEC	Rad50 →	-0.233	-2.807	.028	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

14-3-3_beta by C22orf31 expression — UCEC

Explore this box plot interactively →