C22orf31

Across TCGA cell cohorts, C22orf31 RNA expression is significantly associated with the go_rna of many other GO terms, with 453 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible C22orf31-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, DTMP catabolic process, and Negative regulation of transcription by RNA polymerase I. Each is linked with C22orf31 in more than 3 cancer types. Because this analysis shows association rather than direction, both C22orf31-to-partner and partner-to-C22orf31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by C22orf31-low versus C22orf31-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C22orf31→partner) and Y-score (partner→C22orf31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Epigenetic regulation of gene expression →	+0.048	+0.210	<.001	.007	3	4
BREAST	DTMP catabolic process →	-0.166	-0.055	.001	.008	3	4
SOFT_TISSUE	Negative regulation of transcription by RNA polymerase I →	+0.124	+0.110	<.001	.008	3	3
SOFT_TISSUE	Regulation of mitotic metaphase/anaphase transition →	+0.072	+0.109	.004	.009	3	3
SOFT_TISSUE	Cholesterol biosynthetic process via lathosterol →	+0.134	+0.109	<.001	.009	3	3
CNS	Embryonic brain development →	+0.088	+0.013	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 453 associations by consensus.

Epigenetic regulation of gene expression by C22orf31 expression — SOFT_TISSUE

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