C21orf91

Across TCGA patient cohorts, C21orf91 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,076 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible C21orf91-associated proteins across cancer lineages are WNK2, COPB2, and NCAPH2. Each is linked with C21orf91 in more than 3 cancer types. Because this analysis shows association rather than direction, both C21orf91-to-partner and partner-to-C21orf91 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C21orf91 versus WNK2 in LSCC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C21orf91→partner) and Y-score (partner→C21orf91) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WNK2 →	+0.815	+1.144	<.001	<.001	3	4
BRCA	COPB2 →	-0.219	-0.724	<.001	<.001	3	4
LSCC	NCAPH2 →	+0.357	+0.836	<.001	<.001	3	3
LSCC	VNN2 →	-0.741	-0.806	<.001	<.001	3	3
UCEC	TEX10 →	+0.307	+0.446	<.001	.003	3	3
UCEC	TMOD3 →	-0.285	-0.516	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,076 associations by consensus.

C21orf91 vs WNK2 — LSCC

Explore this scatter interactively →