C21orf91

Across TCGA pan-cancer cohorts, C21orf91 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of C21orf91’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where C21orf91 RNA is repressed in tumor relative to normal tissue. In most cancer types C21orf91 is over-expressed in tumor, although a few such as KICH and LIHC show the opposite, repressed pattern.

KICH, LIHC, and HNSC are the cancer types where C21orf91 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C21orf91 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.029	<.001	10	view →
LIHC	All	II,III,IV	−0.764	<.001	8	view →
HNSC	All	III,IV	+0.691	.004	6	view →
BRCA	Female	All	−0.413	<.001	6	view →
LUAD	All	III,IV	−0.537	.013	3	view →
LUSC	All	All	+0.540	.001	2	view →
UCEC	All	All	−0.490	.027	2	view →
PRAD	All	All	−0.345	.002	2	view →
KIRC	All	All	+0.245	.010	2	view →
THCA	All	All	−0.217	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

C21orf91–KICH

Open the KICH breakdown →