C21orf91

Across TCGA pan-cancer cohorts, C21orf91 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated C21orf91 data layer compared with 2 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C21orf91 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated C21orf91 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, UVM, and KIRC are the cancer types where C21orf91 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.449	0.236	<.001	92	view →
UVM	DFS	Quartile	III,IV	0.215	0.832	.002	52	view →
KIRC	OS	Quartile	All	0.754	0.551	<.001	51	view →
LUSC	OS	Tertile	All	0.732	0.587	.003	47	view →
THYM	DFS	Median	All	0.871	0.646	.001	40	view →
SKCM	DFS	Median	All	0.778	0.672	.005	23	view →
CHOL	DFS	Median	All	0.718	0.132	.005	18	view →
KIRP	DFS	Median	II,III,IV	0.532	0.919	.013	16	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	16	view →
ACC	OS	Median	II,III,IV	0.940	0.772	.021	15	view →
LGG	OS	Tertile	All	0.332	0.480	.006	13	view →
BLCA	DFS	Median	III,IV	0.360	0.165	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

C21orf91–HNSC (DFS)

Open the HNSC breakdown →