C21orf91

Across TCGA patient cohorts, C21orf91 protein abundance is significantly associated with the RNA expression of many other genes, with 3,079 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible C21orf91-associated genes across cancer lineages are SLC18B1, PLEKHS1, and CAPN13. Each is linked with C21orf91 in more than 1 cancer types. Because this analysis shows association rather than direction, both C21orf91-to-partner and partner-to-C21orf91 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C21orf91 versus SLC18B1 in HNSC, with a Pearson correlation of -0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C21orf91→partner) and Y-score (partner→C21orf91) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC18B1 →	-0.920	-0.814	<.001	.008	3	2
HNSC	PLEKHS1 →	-2.085	-0.641	.008	.008	3	2
LSCC	CAPN13 →	-1.877	-0.542	<.001	<.001	3	2
HNSC	LGALS7B →	+3.050	+0.428	.003	.006	3	2
HNSC	ADAM28 →	-1.318	-0.683	.002	.005	3	2
GBM	CPVL →	+0.814	+0.293	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,079 associations by consensus.

C21orf91 vs SLC18B1 — HNSC

Explore this scatter interactively →