C21orf91

Across TCGA patient cohorts, C21orf91 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C21orf91-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and GATA6. Each is linked with C21orf91 in more than 1 cancer types. Because this analysis shows association rather than direction, both C21orf91-to-partner and partner-to-C21orf91 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by C21orf91-low versus C21orf91-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C21orf91→partner) and Y-score (partner→C21orf91) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.235	-1.807	.023	.027	3	1
UCEC	A-Raf_pS299 →	-0.120	-2.584	.014	.010	3	1
UCEC	GATA6 →	-0.183	-3.155	.005	.018	3	1
UCEC	INPP4B →	-0.408	-3.584	.002	.002	3	1
UCEC	JNK2 →	+0.168	+1.807	.041	.027	3	1
UCEC	p27_pT198 →	+0.101	+3.000	.022	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1068 by C21orf91 expression — UCEC

Explore this box plot interactively →