C21orf91-OT1

Across TCGA patient cohorts, C21orf91-OT1 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,578 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible C21orf91-OT1-associated proteins across cancer lineages are PHF2_S905, ZFYVE21, and IRF2BP2. Each is linked with C21orf91-OT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both C21orf91-OT1-to-partner and partner-to-C21orf91-OT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C21orf91-OT1 versus PHF2_S905 in HNSC, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C21orf91-OT1→partner) and Y-score (partner→C21orf91-OT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PHF2_S905 →	+0.753	+0.935	<.001	<.001	3	3
BRCA	ZFYVE21 →	-0.226	-0.290	.006	.005	3	3
LSCC	IRF2BP2 →	+0.259	+1.513	<.001	<.001	3	3
GBM	BAZ1B_S1468 →	+0.361	+0.503	<.001	<.001	3	3
BRCA	ETV6 →	+0.346	+0.365	<.001	<.001	3	3
HNSC	SYTL2 →	-0.768	-0.871	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,578 associations by consensus.

C21orf91-OT1 vs PHF2_S905 — HNSC

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