C21orf91-OT1

Across TCGA pan-cancer cohorts, C21orf91-OT1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated C21orf91-OT1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C21orf91-OT1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated C21orf91-OT1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, PAAD, and BLCA are the cancer types where C21orf91-OT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.509	0.273	<.001	110	view →
PAAD	DFS	Tertile	All	0.391	0.511	.021	45	view →
BLCA	OS	Tertile	III,IV	0.666	0.494	.004	39	view →
LGG	OS	Median	All	0.516	0.381	<.001	37	view →
KIRP	OS	Tertile	II,III,IV	0.151	0.594	.007	27	view →
MESO	DFS	Tertile	IV	0.529	0.245	.026	15	view →
THYM	OS	Tertile	All	0.867	1.000	.015	11	view →
STAD	OS	Tertile	III,IV	0.731	0.524	.022	9	view →
THCA	OS	Tertile	IV	0.813	1.000	.039	9	view →
LUAD	OS	Median	II,III,IV	0.748	0.592	.022	6	view →
CESC	OS	Median	III,IV	0.829	0.631	.024	4	view →
CHOL	DFS	Quartile	All	1.000	0.330	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

C21orf91-OT1–HNSC (DFS)

Open the HNSC breakdown →