C21orf91-OT1

Across TCGA pan-cancer cohorts, C21orf91-OT1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of C21orf91-OT1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where C21orf91-OT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C21orf91-OT1 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

BLCA, LUSC, and COAD are the cancer types where C21orf91-OT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C21orf91-OT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.069	.032	4	view →
LUSC	All	II,III,IV	+0.124	.007	3	view →
COAD	All	II,III,IV	−0.031	.018	3	view →
THCA	Female	All	−0.043	.006	2	view →
LUAD	All	All	+0.126	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

C21orf91-OT1–BLCA

Open the BLCA breakdown →