C20orf173

Across TCGA patient cohorts, C20orf173 mutation is significantly associated with the RNA expression of many other genes, with 457 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C20orf173-associated genes across cancer lineages are OR4M1, RNU6-839P, and SNORA59B. Each is linked with C20orf173 in more than 1 cancer types. Because this analysis shows association rather than direction, both C20orf173-to-partner and partner-to-C20orf173 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4M1 grouped by C20orf173-low versus C20orf173-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C20orf173→partner) and Y-score (partner→C20orf173) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR4M1 →	+0.033	+5.342	<.001	.002	3	2
BRCA	RNU6-839P →	+0.259	+8.471	<.001	.005	3	2
UCEC	SNORA59B →	+0.307	+2.564	<.001	.003	3	2
UCEC	MIR6870 →	+0.527	+2.759	<.001	.006	3	1
UCEC	CYFIP1 →	+0.596	+3.491	.007	.002	3	1
UCEC	ZNF280B →	+0.654	+3.470	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 457 associations by consensus.

OR4M1 by C20orf173 expression — CESC

Explore this box plot interactively →