Across TCGA pan-cancer cohorts, C20orf173 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of C20orf173’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where C20orf173 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C20orf173 is over-expressed in tumor.
KIRC and BLCA are the cancer types where C20orf173 tumor–normal differential expression is most reproducible.