C20orf173

Across TCGA patient cohorts, C20orf173 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C20orf173-associated genes across cancer lineages are FOXO3a_pS318_S321, JNK2, and Ku80. Each is linked with C20orf173 in more than 1 cancer types. Because this analysis shows association rather than direction, both C20orf173-to-partner and partner-to-C20orf173 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by C20orf173-low versus C20orf173-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C20orf173→partner) and Y-score (partner→C20orf173) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.170	-2.999	.009	.035	3	1
UCEC	JNK2 →	+0.239	+2.817	.021	.036	3	1
UCEC	Ku80 →	+0.347	+3.335	.004	.005	3	1
UCEC	mTOR_pS2448 →	-0.225	-3.321	.003	.010	3	1
UCEC	NF-kB-p65_pS536 →	-0.555	-3.321	.019	.010	3	1
UCEC	p70-S6K_pT389 →	-0.235	-3.169	.018	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

FOXO3a_pS318_S321 by C20orf173 expression — UCEC

Explore this box plot interactively →