C1orf50

Across TCGA patient cohorts, C1orf50 mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf50-associated genes across cancer lineages are MIR513A2, RIT2, and POTED. Each is linked with C1orf50 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf50-to-partner and partner-to-C1orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR513A2 grouped by C1orf50-low versus C1orf50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf50→partner) and Y-score (partner→C1orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR513A2 →	+0.165	+4.049	<.001	.008	3	2
UCEC	RIT2 →	+0.113	+3.331	.004	<.001	3	1
UCEC	POTED →	+0.013	+3.630	.001	.003	3	1
UCEC	KIR3DL1 →	+0.248	+4.080	.002	<.001	3	1
UCEC	ANKRD49 →	+0.470	+3.234	.009	.009	3	1
LUAD	OR51A8P →	+0.180	+5.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

MIR513A2 by C1orf50 expression — UCEC

Explore this box plot interactively →