C1orf50

Across TCGA pan-cancer cohorts, C1orf50 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C1orf50’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C1orf50 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C1orf50 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, KICH, and UCEC are the cancer types where C1orf50 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1orf50 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.540	<.001	12	view →
KICH	Female	II,III,IV	−1.475	<.001	10	view →
UCEC	All	All	+0.337	.015	6	view →
KIRC	Female	All	+0.248	.005	6	view →
BLCA	Female	III,IV	+0.418	.021	5	view →
LIHC	All	II,III,IV	+0.365	.002	5	view →
LUAD	Male	All	+0.351	<.001	5	view →
STAD	All	II,III,IV	+0.290	.006	4	view →
KIRP	All	All	−0.273	.001	3	view →
CHOL	Male	All	+0.848	<.001	2	view →
COAD	Female	All	+0.252	.015	2	view →
LUSC	All	All	+0.236	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C1orf50–HNSC

Open the HNSC breakdown →