C1orf21

Across TCGA patient cohorts, C1orf21 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,260 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible C1orf21-associated proteins across cancer lineages are RPL3, C1orf21_S95, and UTP11. Each is linked with C1orf21 in more than 5 cancer types. Because this analysis shows association rather than direction, both C1orf21-to-partner and partner-to-C1orf21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C1orf21 versus RPL3 in GBM, with a Pearson correlation of -0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf21→partner) and Y-score (partner→C1orf21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL3 →	-0.366	-0.740	.001	<.001	3	6
BRCA	C1orf21_S95 →	+0.834	+1.577	.009	.003	3	6
LUAD	UTP11 →	-0.370	-0.844	<.001	<.001	3	5
PDAC	WDR43 →	-0.290	-0.618	<.001	<.001	3	5
LUAD	DNAJB11 →	-0.322	-0.890	<.001	<.001	3	5
GBM	ERO1A →	-0.728	-0.802	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,260 associations by consensus.

C1orf21 vs RPL3 — GBM

Explore this scatter interactively →