C1orf21

Across TCGA pan-cancer cohorts, C1orf21 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C1orf21’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where C1orf21 RNA is repressed in tumor relative to normal tissue. In most cancer types C1orf21 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and LUAD are the cancer types where C1orf21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1orf21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	−1.165	<.001	11	view →
COAD	Female	All	−1.043	<.001	10	view →
LUAD	Male	III,IV	−2.075	<.001	9	view →
UCEC	All	III,IV	−2.441	<.001	8	view →
LUSC	Male	II,III,IV	−0.873	<.001	8	view →
KICH	All	All	−0.887	<.001	5	view →
BRCA	Female	All	−0.397	.002	4	view →
KIRC	All	All	−0.259	.021	4	view →
STAD	Female	All	−1.152	.016	3	view →
CHOL	All	All	+1.109	<.001	2	view →
LIHC	Male	All	+0.629	.010	2	view →
READ	All	All	−1.109	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C1orf21–BLCA

Open the BLCA breakdown →