C1orf21

Across TCGA pan-cancer cohorts, C1orf21 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated C1orf21 data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher C1orf21 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C1orf21 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

UVM, KICH, and KIRP are the cancer types where C1orf21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.337	0.783	<.001	128	view →
KICH	DFS	Median	III,IV	0.305	1.000	<.001	90	view →
KIRP	OS	Tertile	All	0.736	1.000	.001	73	view →
UCS	DFS	Quartile	II,III,IV	0.768	0.116	.001	42	view →
KIRC	DFS	Tertile	II,III,IV	0.410	0.651	.002	32	view →
SKCM	DFS	Quartile	All	0.660	0.528	.005	25	view →
BRCA	OS	Median	III,IV	0.884	0.777	.012	24	view →
READ	DFS	Tertile	All	0.725	0.895	.010	21	view →
THYM	DFS	Tertile	All	0.734	1.000	.007	17	view →
LUAD	OS	Quartile	All	0.577	0.288	.003	17	view →
ACC	DFS	Quartile	III,IV	0.612	0.065	.012	14	view →
LIHC	OS	Tertile	All	0.455	0.684	.007	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

C1orf21–UVM (DFS)

Open the UVM breakdown →