C1orf21

Across TCGA patient cohorts, C1orf21 protein abundance is significantly associated with the RNA expression of many other genes, with 11,270 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible C1orf21-associated genes across cancer lineages are ROBO2, TLE4, and EDEM3. Each is linked with C1orf21 in more than 3 cancer types. Because this analysis shows association rather than direction, both C1orf21-to-partner and partner-to-C1orf21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C1orf21 versus ROBO2 in GBM, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf21→partner) and Y-score (partner→C1orf21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ROBO2 →	+1.232	+0.491	.002	.001	3	4
LUAD	TLE4 →	+0.577	+0.585	<.001	<.001	3	3
BRCA	EDEM3 →	+0.669	+0.851	<.001	<.001	3	3
BRCA	ADIPOR1 →	+0.641	+0.925	<.001	<.001	3	3
BRCA	TIPARP →	+0.695	+0.741	<.001	<.001	3	3
BRCA	KCNK5 →	-1.148	-0.655	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,270 associations by consensus.

C1orf21 vs ROBO2 — GBM

Explore this scatter interactively →