C1orf21

Across TCGA patient cohorts, C1orf21 protein abundance is significantly associated with the protein abundance of many other proteins, with 18,877 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible C1orf21-associated proteins across cancer lineages are C1orf21_S95, ARHGAP4, and ARHGEF12_S1541. Each is linked with C1orf21 in more than 4 cancer types. Because this analysis shows association rather than direction, both C1orf21-to-partner and partner-to-C1orf21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C1orf21 versus C1orf21_S95 in LSCC, with a Pearson correlation of 0.74.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf21→partner) and Y-score (partner→C1orf21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C1orf21_S95 →	+0.835	+0.746	<.001	<.001	3	5
GBM	ARHGAP4 →	-0.424	-0.427	<.001	<.001	3	4
BRCA	ARHGEF12_S1541 →	+0.680	+1.385	<.001	<.001	3	4
BRCA	RNASEL →	+0.482	+0.971	<.001	<.001	3	4
BRCA	ATP1B1 →	+0.551	+0.702	<.001	<.001	3	4
UCEC	NDUFB7 →	+0.513	+0.586	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,877 associations by consensus.

C1orf21 vs C1orf21_S95 — LSCC

Explore this scatter interactively →