C1orf21

Across TCGA patient cohorts, C1orf21 mutation is significantly associated with the RNA expression of many other genes, with 3,722 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf21-associated genes across cancer lineages are RNA5SP369, RN7SKP247, and RNU6-293P. Each is linked with C1orf21 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf21-to-partner and partner-to-C1orf21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP369 grouped by C1orf21-low versus C1orf21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf21→partner) and Y-score (partner→C1orf21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP369 →	+0.269	+1.734	.001	.005	3	2
BLCA	RN7SKP247 →	+0.234	+4.973	<.001	.009	3	1
BLCA	RNU6-293P →	+0.385	+5.038	<.001	.009	3	1
BLCA	BPY2DP →	+0.182	+6.618	<.001	.001	3	1
BLCA	RN7SL554P →	+0.138	+5.685	.004	.003	3	1
BLCA	RNA5SP521 →	+0.437	+4.973	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,722 associations by consensus.

RNA5SP369 by C1orf21 expression — UCEC

Explore this box plot interactively →