C1orf21

Across TCGA patient cohorts, C1orf21 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf21-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4E. Each is linked with C1orf21 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf21-to-partner and partner-to-C1orf21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by C1orf21-low versus C1orf21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf21→partner) and Y-score (partner→C1orf21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.097	-2.088	.007	.016	3	1
UCEC	EGFR_pY1068 →	-0.369	-2.807	<.001	<.001	3	1
UCEC	eIF4E →	+0.196	+3.335	.009	.005	3	1
UCEC	FASN →	+0.289	+1.584	.041	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.122	-1.405	.006	.043	3	1
UCEC	GATA6 →	-0.132	-2.162	.022	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

14-3-3_beta by C1orf21 expression — UCEC

Explore this box plot interactively →