C1orf115

Across TCGA cell cohorts, C1orf115 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible C1orf115-associated genes across cancer lineages are NT5C1A, HTR1E, and OR52L1. Each is linked with C1orf115 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf115-to-partner and partner-to-C1orf115 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NT5C1A grouped by C1orf115-low versus C1orf115-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf115→partner) and Y-score (partner→C1orf115) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NT5C1A →	+0.057	+4.684	<.001	.002	3	2
LARGE_INTESTINE	HTR1E →	+0.066	+4.930	<.001	.001	3	2
LARGE_INTESTINE	OR52L1 →	+0.042	+4.684	<.001	.002	3	2
CNS	BHLHE23 →	+0.022	+5.754	<.001	.002	3	1
CNS	S100G →	+0.183	+5.321	<.001	.005	3	1
CNS	OR52E4 →	+0.029	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

NT5C1A by C1orf115 expression — LARGE_INTESTINE

Explore this box plot interactively →