C1orf115

Across TCGA pan-cancer cohorts, C1orf115 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C1orf115’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where C1orf115 RNA is repressed in tumor relative to normal tissue. In most cancer types C1orf115 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and KIRP are the cancer types where C1orf115 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1orf115 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−3.968	<.001	11	view →
COAD	Female	II,III,IV	−2.638	<.001	11	view →
KIRP	Male	All	−1.313	<.001	11	view →
KIRC	Male	All	−0.633	<.001	11	view →
LUAD	Female	III,IV	−2.572	<.001	8	view →
UCEC	All	III,IV	−1.665	<.001	6	view →
BRCA	All	II,III,IV	−1.523	<.001	6	view →
LUSC	Male	All	−1.311	<.001	6	view →
READ	All	II,III,IV	−2.892	<.001	5	view →
THCA	All	All	+0.791	<.001	4	view →
PRAD	All	All	+0.514	.002	2	view →
CHOL	All	All	−0.777	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C1orf115–KICH

Open the KICH breakdown →