C1orf115

Across TCGA pan-cancer cohorts, C1orf115 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated C1orf115 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher C1orf115 RNA is associated with better overall survival. In most high-consensus cancer types, elevated C1orf115 expression acts as an unfavorable survival marker, although some lineages such as KIRC and OV show a favorable association.

KIRC, KICH, and OV are the cancer types where C1orf115 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.710	0.543	<.001	123	view →
KICH	DFS	Median	III,IV	0.325	1.000	<.001	93	view →
OV	OS	Median	All	0.885	0.794	.001	86	view →
ACC	DFS	Tertile	All	0.272	0.738	<.001	79	view →
UVM	DFS	Tertile	III,IV	0.412	0.911	.001	52	view →
SCLC	OS	Median	All	0.800	0.593	.006	25	view →
LUSC	OS	Tertile	All	0.828	0.690	.001	24	view →
HNSC	DFS	Quartile	IV	0.774	0.384	.004	19	view →
CHOL	DFS	Quartile	II,III,IV	0.240	0.716	.021	18	view →
THCA	OS	Median	II,III,IV	1.000	0.934	.016	18	view →
MESO	OS	Median	All	0.486	0.288	.003	18	view →
ESCA	OS	Tertile	All	0.416	1.000	.022	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

C1orf115–KIRC (OS)

Open the KIRC breakdown →